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Generation and Characterization of dickkopf3 Mutant Mice

  • Ivan del Barco Barrantes
  • Ana Montero-Pedrazuela
  • Ana Guadaño-Ferraz
  • Maria-Jesus Obregon
  • Raquel Martinez de Mena
  • Valérie Gailus-Durner
  • Helmut Fuchs
  • Tobias J. Franz
  • Svetoslav Kalaydjiev
  • Martina Klempt
  • Sabine Hölter
  • Birgit Rathkolb
  • Claudia Reinhard
  • Gabriella Morreale de Escobar
  • Juan Bernal
  • Dirk H. Busch
  • Wolfgang Wurst
  • Eckhard Wolf
  • Holger Schulz
  • Svetlana Shtrom
  • And 4 more
American Society for Microbiology
Publication Date
Mar 01, 2006
  • Biology
  • Chemistry


dickkopf (dkk) genes encode a small family of secreted Wnt antagonists, except for dkk3, which is divergent and whose function is poorly understood. Here, we describe the generation and characterization of dkk3 mutant mice. dkk3-deficient mice are viable and fertile. Phenotypic analysis shows no major alterations in organ morphology, physiology, and most clinical chemistry parameters. Since Dkk3 was proposed to function as thyroid hormone binding protein, we have analyzed deiodinase activities, as well as thyroid hormone levels. Mutant mice are euthyroid, and the data do not support a relationship of dkk3 with thyroid hormone metabolism. Altered phenotypes in dkk3 mutant mice were observed in the frequency of NK cells, immunoglobulin M, hemoglobin, and hematocrit levels, as well as lung ventilation. Furthermore, dkk3-deficient mice display hyperactivity.

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