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Generating novel polyene antifungal drugs.

Authors
  • 1
  • 1 Instituto de Biotecnología INBIOTEC, Parque Científico de León y Area de Microbiología, Facultad de Biología, Universidad de León, 24071 León, Spain. , (Spain)
Type
Published Article
Journal
Chemistry & Biology
1074-5521
Publisher
Elsevier
Publication Date
Volume
12
Issue
5
Pages
509–510
Identifiers
PMID: 15911369
Source
Medline
License
Unknown

Abstract

In this issue of Chemistry & Biology, Francisco Malpartida and colleagues [1] report the formation of novel polyene amide derivatives upon transformation of the producer strain with SCP2*-derived vectors carrying the erythromycin resistance gene ermE. This unexpected finding provides a new tool for generating antifungal drugs by biotransformation.

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