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Generalized immune activation in pulmonary tuberculosis: co-activation with HIV infection.

Authors
  • Vanham, G
  • Edmonds, K
  • Qing, L
  • Hom, D
  • Toossi, Z
  • Jones, B
  • Daley, C L
  • Huebner, B
  • Kestens, L
  • Gigase, P
  • Ellner, J J
Type
Published Article
Journal
Clinical and experimental immunology
Publication Date
Jan 01, 1996
Volume
103
Issue
1
Pages
30–34
Identifiers
PMID: 8565282
Source
Medline
License
Unknown

Abstract

Parameters of immune activation/differentiation were studied in a group of newly diagnosed HIV- and HIV+ pulmonary tuberculosis (TB) patients. Compared with controls, HLA-DR expression on both CD4 and CD8 T cells from the HIV- TB patients was approximately doubled; HLA-DR on T cells from the HIV+ group was tripled. The monocytes from both groups of patients expressed abnormally high levels of the Fc gamma receptors I and III. Serum levels of tumour necrosis factor-alpha (TNF-alpha), neopterin and beta 2-microglobulin were increased in HIV- and even more so in HIV+ TB patients. The expression of HLA-DR on T cell subsets and of Fc gamma R on monocytes correlated with each other, but not with serum activation markers. This pattern of non-specific activation during TB infection may be associated with enhanced susceptibility to HIV infection.

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