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Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development.

Authors
  • Gaydos, Laura J1
  • Wang, Wenchao2
  • Strome, Susan3
  • 1 Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.
  • 2 Department of Biology, Indiana University, Bloomington, IN 47405, USA. , (India)
  • 3 Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA. Department of Biology, Indiana University, Bloomington, IN 47405, USA. [email protected] , (India)
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Sep 19, 2014
Volume
345
Issue
6203
Pages
1515–1518
Identifiers
DOI: 10.1126/science.1255023
PMID: 25237104
Source
Medline
License
Unknown

Abstract

For proper development, cells must retain patterns of gene expression and repression through cell division. Repression via methylation of histone H3 on Lys27 (H3K27me) by Polycomb repressive complex 2 (PRC2) is conserved, but its transmission is not well understood. Our studies suggest that PRC2 represses the X chromosomes in Caenorhabditis elegans germ cells, and this repression is transmitted to embryos by both sperm and oocytes. By generating embryos containing some chromosomes with and some without H3K27me, we show that, without PRC2, H3K27me is transmitted to daughter chromatids through several rounds of cell division. In embryos with PRC2, a mosaic H3K27me pattern persists through embryogenesis. These results demonstrate that H3K27me and PRC2 each contribute to epigenetically transmitting the memory of repression across generations and during development.

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