Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits
- Authors
- Type
- Published Article
- Journal
- Cell Reports
- Publisher
- Elsevier
- Publication Date
- Apr 07, 2020
- Volume
- 31
- Issue
- 1
- Identifiers
- DOI: 10.1016/j.celrep.2020.03.054
- PMID: 32268095
- PMCID: PMC7166081
- Source
- PubMed Central
- Keywords
- License
- Unknown
Abstract
Tissières et al. show that, in comparison to the pentadactyl mouse limb, the expression and regulation of key developmental pathways are altered during pig limb bud development. These changes likely contributed to the morphological evolution of the highly specialized pig limb skeleton, with two weight-bearing and two reduced digits.