Affordable Access

deepdyve-link
Publisher Website

Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits

Authors
  • Tissières, Virginie1
  • Geier, Florian2, 3
  • Kessler, Barbara4
  • Wolf, Eckhard4
  • Zeller, Rolf5
  • Lopez-Rios, Javier1
  • 1 Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, 41013 Seville, Spain
  • 2 4053 Basel, Switzerland
  • 3 Swiss Institute of Bioinformatics, 4058 Basel, Switzerland
  • 4 Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany
  • 5 Developmental Genetics, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Apr 07, 2020
Volume
31
Issue
1
Identifiers
DOI: 10.1016/j.celrep.2020.03.054
PMID: 32268095
PMCID: PMC7166081
Source
PubMed Central
Keywords
License
Unknown

Abstract

Tissières et al. show that, in comparison to the pentadactyl mouse limb, the expression and regulation of key developmental pathways are altered during pig limb bud development. These changes likely contributed to the morphological evolution of the highly specialized pig limb skeleton, with two weight-bearing and two reduced digits.

Report this publication

Statistics

Seen <100 times