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Gene regulation: translational initiation by internal ribosome binding.

Authors
  • Oh, S K1
  • Sarnow, P
  • 1 Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver 80262.
Type
Published Article
Journal
Current Opinion in Genetics & Development
Publisher
Elsevier
Publication Date
Apr 01, 1993
Volume
3
Issue
2
Pages
295–300
Identifiers
PMID: 8504255
Source
Medline
Language
English
License
Unknown

Abstract

During the past year, several examples of cellular mRNAs have been described in which translational initiation occurs by internal ribosome binding, a mechanism hitherto thought to be restricted to picornaviral RNAs. New insights into the molecular mechanism of internal ribosome entry have been provided by the structural and functional analyses of both the internal ribosome entry sites and the protein factors that stimulate translation mediated by these elements.

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