Gene organization and structure of the Streptomyces lividans gal operon.

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Gene organization and structure of the Streptomyces lividans gal operon.

Publication Date
Jan 01, 1988
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

We present the gene organization and DNA sequence of the Streptomyces lividans galactose utilization genes. Complementation of Escherichia coli galE, galT, or galK mutants and DNA sequence analysis were used to demonstrate that the galactose utilization genes are organized within an operon with the gene order galT, galE, and galK. Comparison of the inferred protein sequences for the S. lividans gal gene products to the corresponding E. coli and Saccharomyces carlbergensis sequences identified regions of structural homology within each of the galactose utilization enzymes. Finally, we discuss a potential relationship between the gene organization of the operon and the functional roles of the gal enzymes in cellular metabolism.

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