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Gene of the month: NKX3.1.

Authors
  • Griffin, Jon1, 2
  • Chen, Yuqing3
  • Catto, James W F4, 5
  • El-Khamisy, Sherif2
  • 1 Histopathology Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK [email protected]
  • 2 Healthy Lifespan and Neuroscience Institute, Department of Biosciences, The University of Sheffield, Sheffield, UK.
  • 3 Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • 4 Academic Urology Unit, The University of Sheffield, Sheffield, UK.
  • 5 Urology Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Type
Published Article
Journal
Journal of Clinical Pathology
Publisher
BMJ
Publication Date
Jun 01, 2022
Volume
75
Issue
6
Pages
361–364
Identifiers
DOI: 10.1136/jclinpath-2021-208073
PMID: 34996754
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice. © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

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