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Gene-gene interactions of drug metabolizing enzymes and transporter protein in the risk of upper aerodigestive tract cancers among Indians.

Authors
  • Sam, Soya Sisy
  • Thomas, Vinod
  • Reddy, Kanipakapatanam Sathyanarayana
  • Surianarayanan, Gopalakrishnan
  • Chandrasekaran, Adithan
Type
Published Article
Journal
Cancer epidemiology
Publication Date
Oct 01, 2010
Volume
34
Issue
5
Pages
626–633
Identifiers
DOI: 10.1016/j.canep.2010.05.007
PMID: 20554493
Source
Medline
License
Unknown

Abstract

The findings indicate that the interactions associated with various drug metabolizing enzymes and transporter protein exhibit high risk for UADT cancers than that ascribed to a single susceptible gene. This was particularly established among the polymorphic carriers of CYP1A1*2A, GSTT1 and ABCB1 genes in the population investigated.

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