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Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia.

Authors
  • Washio, Kana1, 2
  • Oka, Takashi2
  • Abdalkader, Lamia2, 3
  • Muraoka, Michiko1
  • Shimada, Akira1
  • Oda, Megumi1
  • Sato, Hiaki2
  • Takata, Katsuyoshi2
  • Kagami, Yoshitoyo4
  • Shimizu, Norio5
  • Kato, Seiichi6
  • Kimura, Hiroshi7
  • Nishizaki, Kazunori8
  • Yoshino, Tadashi2
  • Tsukahara, Hirokazu1
  • 1 a Department of Pediatrics , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan. , (Japan)
  • 2 b Department of Pathology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan. , (Japan)
  • 3 c Department of Pathology, Faculty of Medicine , Mansoura University , Egypt. , (Egypt)
  • 4 d Division of Molecular Medicine , Aichi Cancer Center Research Institute , Nagoya , Japan. , (Japan)
  • 5 e Department of Virology, Division of Virology & Immunology , Medical Research Institute, Tokyo Medical and Dental University , Tokyo , Japan. , (Japan)
  • 6 f Department of Pathology and Laboratory Medicine , Nagoya University Hospital , Nagoya , Japan. , (Japan)
  • 7 g Department of Virology , Nagoya University Graduate School of Medicine , Nagoya , Japan. , (Japan)
  • 8 h Department of Otorhinolaryngology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan. , (Japan)
Type
Published Article
Journal
Leukemia & Lymphoma
Publisher
Informa UK (Taylor & Francis)
Publication Date
Nov 01, 2017
Volume
58
Issue
11
Pages
2683–2694
Identifiers
DOI: 10.1080/10428194.2017.1304762
PMID: 28367723
Source
Medline
Keywords
License
Unknown

Abstract

The human herpes virus, Epstein-Barr virus (EBV), is a known oncogenic virus and plays important roles in life-threatening T/NK-cell lymphoproliferative disorders (T/NK-cell LPD) such as hypersensitivity to mosquito bite (HMB), chronic active EBV infection (CAEBV), and NK/T-cell lymphoma/leukemia. During the clinical courses of HMB and CAEBV, patients frequently develop malignant lymphomas and the diseases passively progress sequentially. In the present study, gene expression of CD16(-)CD56(+)-, EBV(+) HMB, CAEBV, NK-lymphoma, and NK-leukemia cell lines, which were established from patients, was analyzed using oligonucleotide microarrays and compared to that of CD56brightCD16dim/- NK cells from healthy donors. Principal components analysis showed that CAEBV and NK-lymphoma cells were relatively closely located, indicating that they had similar expression profiles. Unsupervised hierarchal clustering analyses of microarray data and gene ontology analysis revealed specific gene clusters and identified several candidate genes responsible for disease that can be used to discriminate each category of NK-LPD and NK-cell lymphoma/leukemia.

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