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[Gene-environment interactions in the pathogenesis and prevention of type 2 diabetes mellitus].

Authors
  • Fritsche, A
  • Thamer, C
  • Stefan, N
  • Häring, H U
Type
Published Article
Journal
Der Internist
Publication Date
Jul 01, 2007
Volume
48
Issue
7
Identifiers
PMID: 17541530
Source
Medline
License
Unknown

Abstract

Type 2 diabetes mellitus is a chronic progressive disease characterized by impaired insulin secretion of the beta cell and impaired insulin sensitivity of different tissues. The incidence of type 2 diabetes mellitus is increasing worldwide, and the disease has reached epidemic proportions. Lifestyle intervention programs are able to delay or possibly prevent the manifestation of type 2 diabetes mellitus. This review summarizes the genetic and environmental factors which influence the risk for type 2 diabetes and their interactions, and determine the success of prevention programs.

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