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The gene encoding the transcriptional repressor BERF-1 maps to a region of conserved synteny on mouse chromosome 16 and human chromosome 3 and a related pseudogene maps to mouse chromosome 8.

Authors
  • Antona, V
  • Cammarata, G
  • De Gregorio, L
  • Dragani, T A
  • Giallongo, A
  • Feo, S
Type
Published Article
Journal
Cytogenetics and cell genetics
Publication Date
Jan 01, 1998
Volume
83
Issue
1-2
Pages
90–92
Identifiers
PMID: 9925940
Source
Medline
License
Unknown

Abstract

We have recently identified and characterized a Kruppel-like zinc finger protein (BERF-1), that functions as a repressor of beta enolase gene transcription. By interspecific backcross analysis the gene encoding BERF-1 was localized 4.7 cM proximal to the Mtv6 locus on mouse chromosome 16, and an isolated pseudogene was localized to mouse chromosome 8, about 5.3 cM distal to the D8Mit4 marker. Nucleotide sequence identity and chomosome location indicate that the gene encoding BERF-1 is the mouse homologue (Zfp148) of ZNF148 localized to human chromosome 3q21, a common translocation site in acute myeloid leukemia patients.

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