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Gene Editing: A New Tool for Viral Disease

Authors
  • Kennedy, Edward M.
  • Cullen, Bryan R.
Type
Published Article
Journal
Annual Review of Medicine
Publisher
Annual Reviews
Publication Date
Jan 14, 2017
Volume
68
Pages
401–411
Identifiers
DOI: 10.1146/annurev-med-051215-031129
Source
Annual Reviews
Keywords
License
Yellow

Abstract

The emergence of the CRISPR/Cas system of antiviral adaptive immunity in bacteria as a facile system for gene editing in mammalian cells may well lead to gene editing becoming a novel treatment for a range of human diseases, especially those caused by deleterious germline mutations. Another potential target for gene editing are DNA viruses that cause chronic pathogenic diseases that cannot be cured by using currently available drugs. We review the current state of this field and discuss the potential advantages and problems with using a gene editing approach as a treatment for diseases caused by DNA viruses.

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