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Gene dosage effect: intraband mapping of human soluble glutamic oxaloacetic transaminase.

Authors
Type
Published Article
Journal
Cytogenetics and cell genetics
Publication Date
Volume
23
Issue
3
Pages
149–156
Identifiers
PMID: 436447
Source
Medline
License
Unknown

Abstract

Quantitative assays of soluble GOT were performed on fibroblasts (from two individuals) with duplications of the long arm of chromosome 10 (10q24 leads to qter). Improved karyologic technique demonstrated that the duplications differ by half a band. Correlation of GOTS activity with the karyologic data indicates that the structural locus for GOTS maps within band 10q24. This study demonstrates the utility of this approach to fine structural mapping of the human genome.

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