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Gender-specific considerations in the antiretroviral management of HIV-infected women.

Authors
  • Clark, Rebecca A
  • Squires, Kathleen E
Type
Published Article
Journal
Expert Review of Anti-infective Therapy
Publisher
"Informa Healthcare (Expert Reviews, LTD)"
Publication Date
Apr 01, 2005
Volume
3
Issue
2
Pages
213–227
Identifiers
PMID: 15918779
Source
Medline
License
Unknown

Abstract

The vast majority of HIV-infected women are of childbearing potential, so issues surrounding reproduction and mother-to-child transmission of the virus are critical in the management of this population. Optimal antiretroviral management of pregnant women is a major global issue since antiretroviral regimens offered to pregnant women to decrease mother-to-child transmission in many countries are often not highly active against HIV. The subsequent emergence of resistant virus can have long-term sequelae for the mother, child, and ultimately, other exposed individuals. The efficacy of antiretroviral therapy appears similar in men and women, although women may experience higher toxicity profiles, which may, in turn, be related to the higher antiretroviral concentrations shown in pharmacokinetic studies. Further investigation into gender-related issues, including sex-associated antiretroviral toxicities, unique pharmacokinetic profiles and optimal antiretroviral management during pregnancy is needed.

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