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Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance.

Authors
  • Kyrklund, Carl
  • Backman, Janne T
  • Neuvonen, Mikko
  • Neuvonen, Pertti J
Type
Published Article
Journal
Clinical pharmacology and therapeutics
Publication Date
Jun 01, 2003
Volume
73
Issue
6
Pages
538–544
Identifiers
PMID: 12811363
Source
Medline
License
Unknown

Abstract

Gemfibrozil increases plasma concentrations of pravastatin. This is partly but not solely the result of the reduced renal clearance of pravastatin. The increase in pravastatin AUC from 0 hours to infinity by gemfibrozil may represent an interference with a transport protein.

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