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Gelatinase secretion by glomerular epithelial cells.

Authors
  • Watanabe, K1
  • Kinoshita, S
  • Nakagawa, H
  • 1 Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan. , (Japan)
Type
Published Article
Journal
Nephron
Publication Date
Jan 01, 1990
Volume
56
Issue
4
Pages
405–409
Identifiers
PMID: 1964201
Source
Medline
License
Unknown

Abstract

A significant increase in gelatinolytic activity was observed in cultures of glomeruli from Heymann nephritic rats. Zymography of the culture medium indicated that the main gelatinase species has a molecular weight of 98 kilodaltons (kDa) and the characteristics of metalloproteinase. The 98-kDa gelatinase was detected in the culture medium of glomerular epithelial cells but not in those of endothelial and mesangial cells. Interleukin-1 beta, tumor necrosis factor-alpha and lipopolysaccharide dose-dependently increased gelatinase production by epithelial cells. These results suggest that the gelatinase secreted by cytokine-stimulated glomerular epithelial cells participates in the pathological process of Heymann nephritis.

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