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GDF15 Induces Anorexia through Nausea and Emesis

Authors
  • Borner, Tito1
  • Shaulson, Evan D.1
  • Ghidewon, Misgana Y.2
  • Barnett, Amanda B.1
  • Horn, Charles C.3, 4, 5
  • Doyle, Robert P.6, 7
  • Grill, Harvey J.2, 8, 9
  • Hayes, Matthew R.1, 10, 8, 9
  • De Jonghe, Bart C.1, 8, 9, 11
  • 1 Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104, USA
  • 2 School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA
  • 3 Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
  • 4 UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
  • 5 Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
  • 6 Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA
  • 7 Department of Medicine, Upstate Medical University, State University of New York, Syracuse, NY 13244, USA
  • 8 Institute of Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA
  • 9 Senior author
  • 10 Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
  • 11 Lead Contact
Type
Published Article
Journal
Cell metabolism
Publication Date
Jan 09, 2020
Volume
31
Issue
2
Pages
351–362
Identifiers
DOI: 10.1016/j.cmet.2019.12.004
PMID: 31928886
PMCID: PMC7161938
Source
PubMed Central
License
Unknown

Abstract

This work assesses whether or not GDF15 produces emesis and/or emetic-like behaviors in the vomiting shrew ( Suncus murinus ) and non-vomiting rat. The results suggest that exogenous delivery of GDF15 produces either emesis or emetic-like behavior (i.e., pica) prior to the induction of anorexia in shrews and rats, respectively.

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