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A GCN-like response in Candida albicans.

Authors
  • Pereira, S A
  • Livi, G P
Type
Published Article
Journal
Cell biology international
Publication Date
Jan 01, 1995
Volume
19
Issue
1
Pages
65–69
Identifiers
PMID: 7613513
Source
Medline
License
Unknown

Abstract

The control of amino acid and purine biosynthesis in the yeast Saccharomyces cerevisiae is mediated by the transcriptional activator GCN4. We previously identified the presence of two putative GCN4 responsive elements (GCREs) in the promoter sequence of the Candida albicans ARO3 gene, which encodes an enzyme in the aromatic amino acid pathway. We now show that amino acid deprivation results in a dramatic rise in the steady-state level of ARO3-specific mRNA, indicative of a GCN-like pathway in C. albicans.

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