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GATA-3 regulates the development and function of invariant NKT cells.

Authors
  • Kim, Peter J
  • Pai, Sung-Yun
  • Brigl, Manfred
  • Besra, Gurdyal S
  • Gumperz, Jenny
  • Ho, I-Cheng
Type
Published Article
Journal
Journal of immunology (Baltimore, Md. : 1950)
Publication Date
Nov 15, 2006
Volume
177
Issue
10
Pages
6650–6659
Identifiers
PMID: 17082577
Source
Medline
License
Unknown

Abstract

Although invariant NKT (iNKT) cells participate in many aspects of immune responses, the molecular mechanisms regulating their development, maturation, and activation are still poorly understood. GATA-3 is a T cell-specific transcription factor that is also expressed in iNKT cells. The critical role of GATA-3 in conventional alphabeta T cells has been well documented, but whether GATA-3 also regulates the development and function of iNKT cells is unknown. In the present study, we report that deficiency of GATA-3 results in cell-intrinsic defects in the thymic development and peripheral maturation of murine iNKT cells. In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent.

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