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Gastrostomy tube placement for long-term oral drug administration in non-human primates.

Authors
  • Kim, Jong-Min1, 2, 3
  • Shin, Jun-Seop1, 2, 3, 4, 5
  • Min, Byoung-Hoon1, 4, 5
  • Kim, Jung-Sik1, 2, 3, 4, 5
  • Yoon, Il-Hee1, 4, 5
  • Jeong, Won-Young1
  • Lee, Ga-Eul1
  • Kim, Min-Sun1
  • Kim, Ju-Eun1
  • Park, Chung-Gyu1, 2, 3, 4, 5, 6
  • 1 Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea. , (North Korea)
  • 2 Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea. , (North Korea)
  • 3 Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. , (North Korea)
  • 4 Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea. , (North Korea)
  • 5 Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea. , (North Korea)
  • 6 Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. , (North Korea)
Type
Published Article
Journal
Xenotransplantation
Publication Date
Mar 01, 2017
Volume
24
Issue
2
Identifiers
DOI: 10.1111/xen.12292
PMID: 28258588
Source
Medline
Keywords
License
Unknown

Abstract

The complication of gastrostomy included a transient inflammation in the skin and peritonitis caused by a leakage around implantation site (one case), which could be overcome by changing suture method and tube type to interlocking box suture and Tri-Funnel Replacement Gastrostomy tube, respectively. Despite these complications, oral drug administration using gastrostomy tube allowed us to perform accurate dosage of drug administration and to reduce the stress that both the monkey and the researcher may experience. Taken together, this study showed that gastrostomy tube placement is a better alternative to oral drug administration in restraint for long-term oral drug administration in rhesus monkeys who tend to refuse to eat the mixture of drug and fruit juice.

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