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Gastroscopic observations following aspirin and naproxen sodium administration.

Authors
  • Halvorsen, L
  • Sevelius, H
Type
Published Article
Journal
Journal of clinical pharmacology
Publication Date
Apr 01, 1981
Volume
21
Issue
4
Pages
169–172
Identifiers
PMID: 7240438
Source
Medline
License
Unknown

Abstract

A double-blind crossover study was conducted to compare the effects of aspirin (3.25 Gm/day) and a new nonsteroidal antiinflammatory drug, naproxen sodium (1.1 Gm/day), on the gastric mucosa of 12 healthy volunteers. Subjects were gastroscoped after one week on each drug, intragastric photographs were obtained, and gastric contents were examined for blood. Ten subjects exhibited some degree of gastric pathology following aspirin administration, compared with one subject with gastric pathology following naproxen sodium. Naproxen sodium also induced less gastrointestinal bleeding and caused fewer side effects than aspirin.

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