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Gastrointestinal involvement in COVID-19 patients: a retrospective study from a Greek COVID-19 referral hospital.

Authors
  • Tsibouris, Panagiotis1
  • Ekmektzoglou, Konstantinos1, 2
  • Agorogianni, Alexandra3
  • Kalantzis, Chrysostomos1
  • Theofanopoulou, Antonia1
  • Toumbelis, Klearchos1
  • Petrogiannopoulos, Leonidas1
  • Poutakidis, Charalambos1
  • Goggaki, Stavroula1
  • Braimakis, Ioannis1
  • Vlachou, Erasmia1
  • Pouliakis, Abraham4
  • Apostolopoulos, Periklis1
  • 1 Department of Gastroenterology, Army Share Fund Hospital (NIMTS), Athens, Greece (Panagiotis Tsibouris, Konstantinos Ekmektzoglou, Chrysostomos Kalantzis, Antonia Theofanopoulou, Klearchos Toumbelis, Leonidas Petrogiannopoulos, Charalambos Poutakidis, Stavroula Goggaki, Ioannis Braimakis, Erasmia Vlachou, Periklis Apostolopoulos). , (Greece)
  • 2 School of Medicine, European University Cyprus, Nicosia, Cyprus (Konstantinos Ekmektzoglou). , (Cyprus)
  • 3 2 Department of Internal Medicine, Army Share Fund Hospital (NIMTS), Athens, Greece (Alexandra Agorogianni). , (Greece)
  • 4 2 Department of Pathology, "ATTIKON" University Hospital, National and Kapodistrian University of Athens, Athens, Greece (Abraham Pouliakis). , (Greece)
Type
Published Article
Journal
Annals of gastroenterology
Publication Date
Jan 01, 2020
Volume
33
Issue
5
Pages
465–472
Identifiers
DOI: 10.20524/aog.2020.0514
PMID: 32879592
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Much attention has been paid to the study and reporting of gastrointestinal (GI) symptoms in COVID-19 patients. Moreover, an increasing number of COVID-19 patients have been noted to experience hepatic and pancreatic injury. In this study, we retrospectively investigated symptoms and laboratory findings related to the GI system in a single center in Athens, Greece, and assessed the role of these parameters in relation to survival and disease severity. We retrospectively studied 61 adult COVID-19 patients admitted to the Army Share Fund Hospital (NIMTS) in Athens, Greece, from April 6th to May 6th, 2020. Sixty-one COVID-19 cases were assessed in the study period. Regarding both survival and disease severity, diarrhea was the most common finding. The multivariate analysis revealed that elevated serum aspartate aminotransferase levels and low serum albumin levels were associated with worse patient survival (odds ratio [OR] 1.029, 95% confidence interval [CI] 1.007-1.05, P=0.0088; and OR 0.219, 95%CI 0.066-0.723, P=0.0127, respectively). As far as disease severity is concerned, only a low serum albumin level (measured at hospital admission) was correlated with more severe disease (OR 0.025, 95%CI 0.004-0.161, P=0.0001). Outpatients with new-onset GI symptoms should be considered for COVID-19 testing in a high COVID-19 prevalence setting, as these symptoms are observed more and more in clinical settings. As prospective studies begin to emerge, clinicians will have more robust research data to diagnose COVID-19 patients earlier and identify patients in need of more intensive treatment. Copyright: © Hellenic Society of Gastroenterology.

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