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Gastrodin protects myocardial cells against hypoxia/reoxygenation injury in neonatal rats by inhibiting cell autophagy through the activation of mTOR signals in PI3K-Akt pathway.

Authors
  • Li, Xiang1
  • Zhu, Qinhui2
  • Liu, Yuanyuan3
  • Yang, Zhiyong4
  • Li, Bin4
  • 1 Department of Clinical Laboratory, the Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, China. , (China)
  • 2 Department of Clinical Laboratory, Huaiyin Hospital of Huai'an City, Huai'an, Jiangsu, China. , (China)
  • 3 Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, China. , (China)
  • 4 Department of Cardiology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, China. , (China)
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Nov 17, 2017
Identifiers
DOI: 10.1111/jphp.12838
PMID: 29148068
Source
Medline
Keywords
License
Unknown

Abstract

Gastrodin could protect against H/R injury of myocardial cells in neonatal rats by reducing the level of autophagy through the activation of mTOR signals in PI3K-Akt pathway.

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