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Gastric cancer in coal miners: an hypothesis of coal mine dust causation.

Authors
  • Ong, T M
  • Whong, W Z
  • Ames, R G
Type
Published Article
Journal
Medical Hypotheses
Publisher
Elsevier
Publication Date
Oct 01, 1983
Volume
12
Issue
2
Pages
159–165
Identifiers
PMID: 6656681
Source
Medline
License
Unknown

Abstract

An hypothesis is proposed to explain the elevated incidence of gastric cancer among coal miners. Inhaled coal mine dust, especially the larger particles, is cleared from the lung and tracheobronchial tree by mucociliary function, swallowed, and introduced into the stomach. Organic and/or inorganic materials in the dust can undergo intra-gastric nitrosation and/or interaction with exogenous chemicals to form carcinogenic compounds which in turn may lead to precancerous lesions, which may subsequently develop into gastric cancer. This sequence of events, however, depends upon occupational exposures as well as life-style features and individual genetic predisposition.

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