Affordable Access

Gas chromatography-chemical ionization mass spectrometry of cocaine and its metabolites in biological fluids.

Authors
  • Chinn, D M
  • Crouch, D J
  • Peat, M A
  • Finkle, B S
  • Jennison, T A
Type
Published Article
Journal
Journal of analytical toxicology
Publication Date
Jan 01, 1980
Volume
4
Issue
1
Pages
37–42
Identifiers
PMID: 6927050
Source
Medline
License
Unknown

Abstract

A gas chromatographic-chemical ionization mass spectrometric (GC-CIMS) method is described for the determination of cocaine, benzoylecgonine, and norcocaine. The procedure uses stable isotopes as internal standards and a mixture of methane-ammonia as chemical ionization reagent gas. Run-to-run and within-run coefficients of variation (%) are less than 10% and the method has a sensitivity of less than 5 ng/mL from 1 mL or 1 gram of sample. The procedure has been applied to a number of cases involving cocaine intoxication and analytical data from these are described.

Report this publication

Statistics

Seen <100 times