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Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe?

Authors
Type
Published Article
Journal
Food and Chemical Toxicology
Publisher
Elsevier
Publication Date
Sep 23, 2016
Volume
95
Identifiers
DOI: 10.1016/j.fct.2016.07.016
Source
LBMCC
Keywords
License
Green

Abstract

In vitro and in vivo studies reported the anti-cancer potential of organosulfur compounds (OSCs) as they trigger biological effects leading to cell cycle arrest with accumulation of cells in G2/M, alteration of the microtubular network, modulation of Bcl-2 family protein expression patterns and changes of the redox status. Despite these well-described effects, no OSC derivative is yet undergoing clinical trials even though their chemistry is well understood as OSCs act as hydrogen sulfide (H 2 S) donors. H 2 S is a …

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