Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe?
- Authors
- Type
- Published Article
- Journal
- Food and Chemical Toxicology
- Publisher
- Elsevier
- Publication Date
- Sep 23, 2016
- Volume
- 95
- Identifiers
- DOI: 10.1016/j.fct.2016.07.016
- Source
- LBMCC
- Keywords
- License
- Green
Abstract
In vitro and in vivo studies reported the anti-cancer potential of organosulfur compounds (OSCs) as they trigger biological effects leading to cell cycle arrest with accumulation of cells in G2/M, alteration of the microtubular network, modulation of Bcl-2 family protein expression patterns and changes of the redox status. Despite these well-described effects, no OSC derivative is yet undergoing clinical trials even though their chemistry is well understood as OSCs act as hydrogen sulfide (H 2 S) donors. H 2 S is a …