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Gamma-tubulin complexes and microtubule nucleation.

Authors
Type
Published Article
Journal
Current Opinion in Structural Biology
0959-440X
Publisher
Elsevier
Publication Date
Volume
11
Issue
2
Pages
174–181
Identifiers
PMID: 11297925
Source
Medline
License
Unknown

Abstract

Microtubules are dynamic cytoskeletal polymers that assemble from alpha/beta-tubulin and are vital for the establishment of cell polarity, vesicle trafficking and formation of the mitotic/meiotic spindle. gamma-Tubulin, a protein related to alpha/beta-tubulin, is required for initiating the polymerization of microtubules in vivo. gamma-Tubulin has been found in two main protein complexes: the gamma-tubulin ring complex and its subunit, the gamma-tubulin small complex. The latter is analogous to the yeast Tub4 complex. In the past year, important advances have been made in understanding the structure and function of the gamma-tubulin ring complex and how it interacts with microtubules.

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