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Gamma Knife radiosurgery for intracranial hemangioblastoma.

Authors
  • Silva, Danilo1
  • Grabowski, Mathew M2
  • Juthani, Rupa2
  • Sharma, Mayur2
  • Angelov, Lilyana2
  • Vogelbaum, Michael A2
  • Chao, Samuel2
  • Suh, John2
  • Mohammadi, Alireza2
  • Barnett, Gene H2
  • 1 Rose Ella Burkhardt Brain Tumor Center, Department of Neurosurgery and Radiation Oncology, Neurological Institute, Cleveland Clinic, OH 44124, USA. Electronic address: [email protected]om.
  • 2 Rose Ella Burkhardt Brain Tumor Center, Department of Neurosurgery and Radiation Oncology, Neurological Institute, Cleveland Clinic, OH 44124, USA.
Type
Published Article
Journal
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Publication Date
Sep 01, 2016
Volume
31
Pages
147–151
Identifiers
DOI: 10.1016/j.jocn.2016.03.008
PMID: 27422585
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Gamma knife radiosurgery (GKRS) has become a treatment option for intracranial hemangioblastomas, especially in patients with poor clinical status and also high-risk surgical candidates. The objective of this study was to analyze clinical outcome and tumor control rates. Retrospective chart review revealed 12 patients with a total of 20 intracranial hemangioblastomas treated with GKRS from May 1998 until December 2014. Kaplan-Meier plots were used to calculate the actuarial local tumor control rates and rate of recurrence following GKRS. Univariate analysis, including log rank test and Wilcoxon test were used on the Kaplan-Meier plots to evaluate the predictors of tumor progression. Two-tailed p value of <0.05 was considered as significant. Median follow-up was 64months (2-184). Median tumor volume pre-GKRS was 946mm(3) (79-15970), while median tumor volume post-GKRS was 356mm(3) (30-5404). Complications were seen in two patients. Tumor control rates were 100% at 1year, 90% at 3years, and 85% at 5years, using the Kaplan-Meier method. There were no statistically significant univariate predictors of progression identified, although there was a trend towards successful tumor control in solid tumors (p=0.07). GKRS is an effective and safe option for treating intracranial hemangioblastoma with favorable tumor control rates. Copyright © 2016 Elsevier Ltd. All rights reserved.

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