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The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin.

Authors
  • Cooney, J
  • Kienle, Z
  • Foster, T J
  • O'Toole, P W
Type
Published Article
Journal
Infection and immunity
Publication Date
Feb 01, 1993
Volume
61
Issue
2
Pages
768–771
Identifiers
PMID: 8423103
Source
Medline
License
Unknown

Abstract

The Staphylococcus aureus gamma-hemolysin comprises two polypeptides, whereas the gamma-hemolysin locus (hlg) contains three open reading frames. The hlgA and hlgB genes encode the gamma 1 and gamma 2 components, respectively. The HlgB protein (gamma 2) has 27% residue identity with S. aureus alpha-toxin. Surprisingly, hlgB and hlgC are 98.5 and 99.1% identical to the lukF and lukS genes, respectively, encoding the F and S components of the Panton-Valentine leukocidin.

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