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gamma delta T-cell receptor-positive T-cell clones derived from human heart transplants do not show donor-specific cytotoxicity.

Authors
Type
Published Article
Journal
Human Immunology
0198-8859
Publisher
Elsevier
Publication Date
Volume
28
Issue
2
Pages
170–174
Identifiers
PMID: 2141011
Source
Medline
License
Unknown

Abstract

gamma delta T-cell receptor-positive T-cell clones were obtained from three endomyocardial biopsies taken from two patients. Clones obtained from two biopsies from patient A, one taken during rejection and one after resolution of this rejection, were WT31-, 11F2+, Ti gamma A-, delta TcS1+. Clones from patient B grown from a biopsy without histologic signs of rejection were either WT31-, 11F2+, Ti gamma A+, delta TcS1-, or WT31+. All gamma delta T-cell receptor-positive clones had cytolytic potential but did not demonstrate donor-specific lysis.

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