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Gamma Delta T Cell Function in Ruminants.

Authors
  • Guerra-Maupome, Mariana1
  • Slate, Jamison R1
  • McGill, Jodi L2
  • 1 Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, 1907 Christensen Drive, VMRI Building 5, Ames, IA 50010, USA.
  • 2 Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, 1907 Christensen Drive, VMRI Building 5, Ames, IA 50010, USA. Electronic address: [email protected]
Type
Published Article
Journal
The Veterinary clinics of North America. Food animal practice
Publication Date
Nov 01, 2019
Volume
35
Issue
3
Pages
453–469
Identifiers
DOI: 10.1016/j.cvfa.2019.08.001
PMID: 31590897
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Gamma delta (γδ) T cells constitute a major lymphocyte population in peripheral blood and epithelial surfaces. They play nonredundant roles in host defense against diverse pathogens. Although γδ T cells share functional features with other cells of the immune system, their distinct methods of antigen recognition, rapid response, and tissue tropism make them a unique effector population. This review considers the current state of our knowledge on γδ T cell biology in ruminants and the important roles played by this nonconventional T cell population in protection against several infectious diseases of veterinary and zoonotic importance. Copyright © 2019 Elsevier Inc. All rights reserved.

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