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Galangin dampens mice lipopolysaccharide-induced acute lung injury.

Authors
  • Shu, Yu-Sheng
  • Tao, Wei
  • Miao, Qian-Bing
  • Lu, Shi-Chun
  • Zhu, Ya-Bing
Type
Published Article
Journal
Inflammation
Publisher
Springer-Verlag
Publication Date
Oct 01, 2014
Volume
37
Issue
5
Pages
1661–1668
Identifiers
DOI: 10.1007/s10753-014-9894-1
PMID: 24743919
Source
Medline
License
Unknown

Abstract

Galangin, an active ingredient of Alpinia galangal, has been shown to possess anti-inflammatory and antioxidant activities. Inflammation and oxidative stress are known to play vital effect in the pathogenesis of acute lung injury (ALI). In this study, we determined whether galangin exerts lung protection in lipopolysaccharide (LPS)-induced ALI. Male BALB/c mice were randomized to receive galangin or vehicle intraperitoneal injection 3 h after LPS challenge. Samples were harvested 24 h post LPS administration. Galangin administration decreased biochemical parameters of oxidative stress and inflammation, and improved oxygenation and lung edema in a dose-dependent manner. These protective effects of galangin were associated with inhibition of nuclear factor (NF)-κB and upregulation of heme oxygenase (HO)-1. Galangin reduces LPS-induced ALI by inhibition of inflammation and oxidative stress.

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