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The GABAergic System of the Basolateral Nucleus of the Amygdaloid Complex of the Brain in Formation of Alcohol Dependence

Authors
  • Akhmadeev, A. V.1
  • Kalimullina, L. B.1
  • 1 Bashkir State University, Ufa, Russia , Ufa (Russia)
Type
Published Article
Journal
Neuroscience and Behavioral Physiology
Publisher
Springer US
Publication Date
Apr 26, 2019
Volume
49
Issue
4
Pages
463–467
Identifiers
DOI: 10.1007/s11055-019-00756-6
Source
Springer Nature
Keywords
License
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Abstract

This review provides the first systematic report of the literature on impairments to GABAergic transmission in the basolateral nucleus of the amygdaloid complex of the brain, leading to increases in anxiety levels. Increases in anxiety are regarded as the main factor prompting alcohol cravings and producing the manifestations of alcohol dependence. Structural-functional rearrangements of ionotropic and metabotropic GABA receptors in acute and chronic exposure to ethanol and withdrawal syndrome are discussed. Data in the role of GABA transporters in the pathogenesis of alcoholism are presented.

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