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[GABAC receptors: structure and functions].

Authors
  • Perfilova, V N
  • Tiurenkov, I N
Type
Published Article
Journal
Eksperimental'naia i klinicheskaia farmakologiia
Publication Date
Jan 01, 2011
Volume
74
Issue
1
Pages
45–49
Identifiers
PMID: 21476276
Source
Medline
License
Unknown

Abstract

Data on the structure, localization, physiology and pharmacology of GABA(C) receptors are reviewed. Thece receptors belong to cys-loop receptors and consist of rho1-3 subunits representing pentamers with five subunits that form a chloride channel. They are found in both central nervous system and peripheral organs. The pentamer can be homomeric, consisting of five similar protomers (e.g., p1), or heteromeric (pseudo-homomeric), consisting of rho1 and rho2 subunits. Chloride channel function also depends on the GABA(C) receptor subunit composition. The activation of GABAc receptors is accompanied by a change in the permeability of plasmatic membranes for C1 ions, which is followed by depolarization (presynaptic inhibition) or hyperpolarization (postsynaptic inhibition). There are a great number of the allosteric modulators, agonists and antagonists of GABA(C) receptors.

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