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GABA | Mechanisms of GABA A Receptor Gene Regulation in Epilepsy

Authors
  • Lund, I.V.
  • Hu, Y.
  • Russek, S.J.
  • Brooks-Kayal, A.R.
Type
Book
Journal
Encyclopedia of Basic Epilepsy Research
Publication Date
Jan 01, 2009
Pages
294–298
Identifiers
DOI: 10.1016/B978-012373961-2.00035-7
ISBN: 978-0-12-373961-2
Source
Elsevier
Keywords
License
Unknown

Abstract

In many cases of temporal lobe epilepsy (TLE), there is an initial precipitating event such as a head injury or prolonged seizure, which is followed by a latent period of months to years before spontaneous seizures occur. Expression of the GABA A receptor (GABA AR) α1 and α4 subunits changes during this latent period, and the mechanisms regulating these changes are therefore targets for research into the molecular mechanisms that contribute to epileptogenesis. Seizure-induced transcriptional regulators of GABA AR α1 and α4 subunit – genes such as CREB, ICER, Egr3, and BDNF – have recently been identified and may provide new therapeutic insights in epilepsy.

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