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GABA alterations in pediatric sport concussion.

Authors
  • Friedman, Seth D1
  • Poliakov, Andrew V1
  • Budech, Christopher1
  • Shaw, Dennis W W1
  • Breiger, David1
  • Jinguji, Thomas1
  • Krabak, Brian1
  • Coppel, David1
  • Lewis, Tressa Mattioli1
  • Browd, Samuel1
  • Ojemann, Jeffrey G2
  • 1 From the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.
  • 2 From the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle. [email protected]
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Nov 21, 2017
Volume
89
Issue
21
Pages
2151–2156
Identifiers
DOI: 10.1212/WNL.0000000000004666
PMID: 29030453
Source
Medline
License
Unknown

Abstract

GABA/Cre appears increased in a region colocalized with working memory task activation after sport concussion. Further work extending these results in larger samples and at time points across the injury episode will aid in refining the clinical significance of these observations.

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