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G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting

Authors
  • Bosma, Karin J.1
  • Rahim, Mohsin2
  • Oeser, James K.1
  • McGuinness, Owen P.1
  • Young, Jamey D.1, 2
  • O'Brien, Richard M.1
  • 1 Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
  • 2 Department of Chemical and Biomolecular Engineering, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
Jun 20, 2020
Volume
41
Identifiers
DOI: 10.1016/j.molmet.2020.101043
PMID: 32569842
PMCID: PMC7369601
Source
PubMed Central
Keywords
License
Unknown

Abstract

• G6pc2 deletion lowers fasting blood glucose (FBG) in chow and high fat fed mice. • Elevated FBG increases the risk of cardiovascular-associated mortality (CAM). • G6pc2 deletion results in hypoglycemia in mice on a ketogenic diet. • G6pc2 deletion results in hypoglycemia in mice following prolonged fasting. • G6PC2 inhibitors may prevent CAM but increase risk of hypoglycemia.

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