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γ Subunit of the AP-1 Adaptor Complex Binds Clathrin: Implications for Cooperative Binding in Coated Vesicle Assembly

Authors
  • Balraj Doray
  • Stuart Kornfeld
Publisher
The American Society for Cell Biology
Publication Date
Jul 01, 2001
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

Fig. 1. Sequence comparison of the hinge of mouse γ (mγ), human γ (hγ), human γ2 (hγ2), and human α (hα) adaptins, and GST-γ adaptin fusion constructs. Doray B , and Kornfeld S Mol. Biol. Cell 2001;12:1925-1935 Copyright © 2001 The American Society for Cell Biology Sequence comparison of the hinge of mouse γ (mγ), human γ (hγ), human γ2 (hγ2), and human α (hα) adaptins, and GST-γ adaptin fusion constructs. (A) Schematic of γ adaptin showing the trunk (T), the hinge (H), and the appendage (A) also called the ear. An alignment of part of the hinge region shows that only γ and γ2 adaptin but not α adaptin possess a variant of the consensus clathrin binding sequence (underlined). (B) Construction of the various GST-γ adaptin fusion proteins is described under MATERIALS AND METHODS.

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