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[G-proteins coupled receptors].

Authors
Type
Published Article
Journal
La Revue du praticien
Publication Date
Volume
44
Issue
9
Pages
1163–1167
Identifiers
PMID: 7939337
Source
Medline
License
Unknown

Abstract

The superfamily of G protein-coupled receptors plays a major role in the transmission and amplification of extracellular stimuli. These membrane receptors have a common structure made of a single polypeptide chain including seven transmembrane spanning domains. The comparison of amino acid sequences of the various G protein-coupled receptors reveals several conserved amino acids and regions playing a key role in ligand binding, G protein coupling, and activation of intracellular second messengers. Mutations of amino acid sequences of seven transmembrane domain receptors and their coupled G proteins are responsible for various human diseases including certain kinds of cancer.

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