Future possibilities in the prevention of breast cancer: Role of genetic variation in breast cancer prevention

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Future possibilities in the prevention of breast cancer: Role of genetic variation in breast cancer prevention

Publisher
BioMed Central
Publication Date
Jan 01, 2000
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

Risk factors for breast cancer are related to endogenous hormonesand reproductive events. As such, traditional cancer prevention strategies arenot easily applicable. Tamoxifen and other selective estrogen receptormodulators (SERMs) offer a new preventive strategy for some high-risk women,but have not yet been shown to be efficacious for all women. New tools toidentify high-risk women are needed. One such tool is the development of amultigenic model of breast cancer susceptibility that can be used to screenwomen in order to identify those who carry a combination of alleles that putsthem at significantly increased risk.

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