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The Future of Gene-Guided Neuroscience Research in Non-Traditional Model Organisms

Authors
  • Juntti, Scott
Type
Published Article
Journal
Brain, Behavior and Evolution
Publisher
S. Karger AG
Publication Date
Aug 15, 2019
Volume
93
Issue
2-3
Pages
108–121
Identifiers
DOI: 10.1159/000500072
PMID: 31416064
Source
Karger
Keywords
License
Green
External links

Abstract

Natural variations across animals in form, function, and behavior have long been sources of inspiration to scientists. Despite this, experimentalists focusing on the neural bases of behavior have increasingly focused on a select few model species. This consolidation is motivated primarily by the availability of resources and technologies for manipulation in these species. Recent years have witnessed a proliferation of experimental approaches that were developed primarily in traditional model species, but that may in principle be readily applied to any species. High-throughput sequencing, CRISPR gene editing, transgenesis, and other technologies have enabled new insights through their deployment in non-traditional model species. The availability of such approaches changes the calculation of which species to study, particularly when a trait of interest is most readily observed in a non-traditional model organism. If these technologies are widely adopted in many new species, it promises to revolutionize the field of neuroethology.

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