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Further substantiation of a significant role for the sympathetic nervous system in inflammation.

Authors
  • Green, P G
  • Luo, J
  • Heller, P H
  • Levine, J D
Type
Published Article
Journal
Neuroscience
Publication Date
Aug 01, 1993
Volume
55
Issue
4
Pages
1037–1043
Identifiers
PMID: 8232896
Source
Medline
License
Unknown

Abstract

This study provides significant new evidence substantiating a role of the postganglionic sympathetic neuron in plasma extravasation in the knee-joint of the rat. Increased plasma extravasation produced by the potent inflammatory mediator bradykinin was mimicked by 6-hydroxydopamine, a selective stimulator of sympathetic fibers. Various treatments (chemical sympathectomy, co-perfusion with the local anesthetic lidocaine, or co-perfusion with depolarizing concentrations of potassium) similarly modulated plasma extravasation induced by both bradykinin and 6-hydroxydopamine, but not that produced by platelet activating factor. We also showed that bradykinin is able to release norepinephrine in the knee-joint, indicating action on the sympathetic postganglionic neuron. In summary, these experiments provide substantial additional evidence supporting a significant contribution of the sympathetic post-ganglionic neuron terminal to inflammatory plasma extravasation.

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