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Further studies on the development of Wuchereria bancrofti in laboratory animals.

Authors
  • Cross, J H
  • Partono, F
  • Hsu, M Y
  • Ash, L R
  • Oemijati, S
Type
Published Article
Journal
The Southeast Asian journal of tropical medicine and public health
Publication Date
Mar 01, 1981
Volume
12
Issue
1
Pages
114–122
Identifiers
PMID: 7020095
Source
Medline
License
Unknown

Abstract

In an attempt to obtain a small animal laboratory model for Wuchereria bancrofti Mongolian gerbils and hamsters were infected with third-stage larvae of strains of the parasite from Indonesia and China. Gerbils were necropsied at 7 to 591 days and larvae recovered up to 219 days. The third molt occurred on or before 10 days and worms found after 14 days were in the fourth stage. More worms were recovered early in the infection (7 to 30 days) than in older infections. The worms were usually recovered from the testes, pelt and carcass and heart and lungs. An adult male worm was recovered on one occasion from the lung of a gerbil at 92 days. The parasite was also found to develop in hamsters with results similar to those in gerbils. Gerbils and hamsters were given antithymocyte sera before and after infection and more worms were recovered and the worms larger in size in some treated animals. Continued studies with geographic strains of W. bancrofti in various animals should be encouraged in order to find a small laboratory animal model for the parasite.

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