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Further studies on the action of baclofen on neurons of the dorsolateral septal nucleus of the rat, in vitro.

Authors
  • Stevens, D R
  • Gallagher, J P
  • Shinnick-Gallagher, P
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Dec 09, 1985
Volume
358
Issue
1-2
Pages
360–363
Identifiers
PMID: 2416388
Source
Medline
License
Unknown

Abstract

Baclofen hyperpolarizes rat dorsolateral septal neurons in a concentration-dependent manner. The apparent dissociation constant for this action is 200 nM. The baclofen-induced hyperpolarization is due to an increase in potassium conductance with a reversal potential of -88 mV. Of the various potassium and calcium channel blockers we tested, only 4-aminopyridine blocked baclofen-induced hyperpolarizations. Our results suggest that baclofen does not activate a calcium-dependent potassium conductance.

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