Affordable Access

Further studies on the action of baclofen on neurons of the dorsolateral septal nucleus of the rat, in vitro.

Authors
Type
Published Article
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
358
Issue
1-2
Pages
360–363
Identifiers
PMID: 2416388
Source
Medline
License
Unknown

Abstract

Baclofen hyperpolarizes rat dorsolateral septal neurons in a concentration-dependent manner. The apparent dissociation constant for this action is 200 nM. The baclofen-induced hyperpolarization is due to an increase in potassium conductance with a reversal potential of -88 mV. Of the various potassium and calcium channel blockers we tested, only 4-aminopyridine blocked baclofen-induced hyperpolarizations. Our results suggest that baclofen does not activate a calcium-dependent potassium conductance.

Statistics

Seen <100 times