Baclofen hyperpolarizes rat dorsolateral septal neurons in a concentration-dependent manner. The apparent dissociation constant for this action is 200 nM. The baclofen-induced hyperpolarization is due to an increase in potassium conductance with a reversal potential of -88 mV. Of the various potassium and calcium channel blockers we tested, only 4-aminopyridine blocked baclofen-induced hyperpolarizations. Our results suggest that baclofen does not activate a calcium-dependent potassium conductance.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2416388