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A further pancreatic carcinogen in Syrian golden hamsters: N-nitroso-bis(2-acetoxypropyl)amine.

Authors
  • Pour, P
  • Althoff, J
  • Gingell, R
  • Kupper, R
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Mar 01, 1976
Volume
1
Issue
4
Pages
197–202
Identifiers
PMID: 1016944
Source
Medline
License
Unknown

Abstract

Weekly subcutaneous injection of N-nitroso-bis(2-acetoxypropyl)amine (BAP) for 20 weeks to Syrian golden hamsters induced pancreatic neoplasms in 50% of the animals, as early as 15 weeks from the start of treatment. The carcinogenic potency and organotropic spectrum of BAP were similar to those of N-nitroso-bis(2-hydroxypropyl)amine (BHP). Metabolism studies indicated that BAP was readily converted in vivo to BHP and that BHP was also the major urinary metabolite.

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