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Further evidence of permanent behavioural changes in rats treated neonatally with neurodrugs.

Authors
  • Dörner, G
Type
Published Article
Journal
Endokrinologie
Publication Date
Jan 01, 1976
Volume
68
Issue
3
Pages
345–348
Identifiers
PMID: 1009911
Source
Medline
License
Unknown

Abstract

Pargyline or reserpine treatment of male rats during the first two weeks of life resulted in significantly increased exploratory activity (sniffing) associated with a significantly decreased emotional reactivity (defecation rate) in adult life. These findings suggest that nonphysiological concentrations and/or turnover rates of neurotransmitters during brain differentiation apparently produced by neurodrugs can lead to permanent behavioural changes.

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