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Furanosesquiterpenoids of Commiphora myrrha.

Authors
  • Zhu, N
  • Kikuzaki, H
  • Sheng, S
  • Sang, S
  • Rafi, M M
  • Wang, M
  • Nakatani, N
  • DiPaola, R S
  • Rosen, R T
  • Ho, C T
Type
Published Article
Journal
Journal of natural products
Publication Date
Nov 01, 2001
Volume
64
Issue
11
Pages
1460–1462
Identifiers
PMID: 11720534
Source
Medline
License
Unknown

Abstract

An investigation on the gum exudates of Commiphora myrrha has led to the isolation of six sesquiterpenoids. On the basis of spectroscopic data interpretation, they were determined as two new furanosesquiterpenoids, rel-1S,2S-epoxy-4R-furanogermacr-10(15)-en-6-one (1) and rel-2R-methyl-5S-acetoxy-4R-furanogermacr-1(10)Z-en-6-one (2), and four known furanosesquiterpenoids, rel-3R-methoxy-4S-furanogermacra-1E,10(15)-dien-6-one (3), rel-2R-methoxy-4R-furanogermacr-1(10)E-en-6-one (4), furanogermacra-1(10)Z,4Z-dien-6-one, and curzerenone [6,7-dihydro-5beta-isopropenyl-3,6beta-dimethyl-6-vinylbenzofuran-4(5H)-one]. This is the first report of the relative stereochemistry for the known compounds 3 and 4. Compound 1 exhibited weak cytotoxic activity against a MCF-7 breast tumor cell line in a clonogenic assay, while the other five compounds were inactive in this assay.

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