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Furan-containing thiacyanine analogs and their antimicrobial activity

Authors
  • Kortišová, I.
  • Foltínová, P.
  • Halgaš, J.
Type
Published Article
Journal
Chemical Papers
Publisher
Versita
Publication Date
Feb 01, 2006
Volume
60
Issue
1
Pages
52–55
Identifiers
DOI: 10.2478/s11696-006-0009-9
Source
De Gruyter
License
Green

Abstract

Condensation of quaternary 2-methylbenzothiazolium bromides with 5-(dialkylamino)furan-2-carbaldehydes afforded a series of new thiacyanine analogs. The compounds exhibit significant activities against several bacterial, yeast, and mould strains. Derivatives with dipropylamino substituents showed higher inhibitory effects than those with cyclic secondary amino groups. Hence, the biological activity may have been influenced by the lipophilicity of the compounds. The effect on growth and on the plastid system of the unicellular flagellate Euglena gracilis was also studied.

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