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A fungicidal piperazine-1-carboxamidine induces mitochondrial fission-dependent apoptosis in yeast.

Authors
  • Bink, Anna
  • Govaert, Gilmer
  • François, Isabelle E J A
  • Pellens, Klaartje
  • Meerpoel, Lieven
  • Borgers, Marcel
  • Van Minnebruggen, Geert
  • Vroome, Valérie
  • Cammue, Bruno P A
  • Thevissen, Karin
Type
Published Article
Journal
FEMS Yeast Research
Publisher
Oxford University Press
Publication Date
Nov 01, 2010
Volume
10
Issue
7
Pages
812–818
Identifiers
DOI: 10.1111/j.1567-1364.2010.00663.x
PMID: 20726898
Source
Medline
License
Unknown

Abstract

To unravel the working mechanism of the fungicidal piperazine-1-carboxamidine derivative BAR0329, we found that its intracellular accumulation in Saccharomyces cerevisiae is dependent on functional lipid rafts. Moreover, BAR0329 induced caspase-dependent apoptosis in yeast, in which the mitochondrial fission machinery consisting of Fis1 (Whi2), Dnm1 and Mdv1 is involved. Our data are consistent with a prosurvival function of Fis1 (Whi2) and a proapoptotic function of Dnm1 and Mdv1 during BAR0329-induced yeast cell death.

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